In order to reach specific areas, the player must equip gear that is suited for that area, or obtain specific vehicles, such as an air balloon or jet skis. Throughout the game, players can also change their abilities, looks by mutations, and apply upgrades to their robotic companion, which can be used to get various advantages against certain enemies or at certain locations. Most moves are based on weapons, which can be crafted using the game's weapon crafting system. Another way to learn new moves is by interacting with specific characters in each area. Besides leveling up the playable character, the player can also use level up points to strengthen their attributes or to unlock new attack combinations. The protagonist is able to dodge to the left, right, and backward, as well as jump. The player can combine the power of multiple weapons by switching between different weapons during combat. When a cryogenic part is put onto a weapon, enemies will freeze when hit. The game features a variety of Affixes, including cryogenic and electrical, which are effective in battles. Each part has its own effect on the statistics of the end product. The player collects parts throughout the game and combines these parts to create a weapon.

The combat system combines melee attacks with long-range shooting.

A thicker character is heavier, which makes it slower but conversely allows it to deal and resist more damage. Players first customize their character including length, body shape and thickness, fur, fangs, and many other attributes that can be tweaked and all have direct impact on the statistics of the playable character during gameplay. Biomutant is an action role-playing game set in an open world environment and played from a third-person perspective in which the player takes control of a mammalian warrior in a world filled with mutated animals.

Biomutant tribe locations